Biology of Disease

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X]VeiZg&+/ MEMBRANE, ORGANELLE AND CYTOSKELETAL DISORDERS


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Recycling of
adapter and
import receptor
proteins

Cargo

Ran GDP

Ran GTP

GDP

GDP

GTP

GTP

GTP

GTP

Adapter
protein

Import
receptor

CARGO IN
CYTOPLASM

CARGO IN
NUCLEOPLASM

Figure 16.2 A highly simplified outline of the nucleocytoplasmic transport of a protein. Thin continuous arrows
represent the formation and dissociation of protein complexes and the thick arrows their transport. The thin broken
arrows indicate the recycling of the adapter and import receptor proteins.See text for details.
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