Biology of Disease

may be due to increased bone resorption or to local cytokine

and prostaglandin synthesis. Also, tumors such as squamous cell

carcinomas of the lungs, may produce PTHrp that has PTH like activity

leading to hypercalcemia.

CHAPTER 9

1 d

2. (a) 10^3 or 1000

(b) pH = 4.94

3. (a) [HCO 3 – ] is 32 mmol dm–3

(b) Alkalosis

(c) Metabolic

4. c

CHAPTER 10

1. c


2. d


3. ATP7A Menkes’ disease

bulimia nervosa dental erosion

copper Wilson’s disease

iodide goiter

fluoride dental caries

folic acid green leafy vegetables

leptin OBESE/obese

molybdenum xanthine oxidase

edema kwashiorkor

pantothenic acid acetyl CoA

saturated fats heart disease

thiamin Wernicke-Korsakoff syndrome

vitamin B 1 thiaminase

vitamin B 6 tryptophan

vitamin B 12 Crohn’s disease

vitamin C scurvy

vitamin D osteomalacia

vitamin E hemolytic anemia

vitamin K prothrombin time

zinc phytanic acid

4. All the plant foods are deficient in some essential amino acids. It is
   therefore vital that your daughter eats a broad mix of cereals, nuts
   and vegetable, especially combining cereals with legumes and/or nuts,
   to ensure she receives adequate amounts of each.


5. There is some clinical evidence of PEMT and iron deficiency. The
   petechial hemorrhages and gum disease are typical of scurvy, which
   arises due to vitamin C deficiency. This is often seen in elderly patients
   who are on a poor diet.


6. Values for BMI for A and B are 23.13 and 37.04 kg m–2respectively.

Theoretical ideal body weights for A and B of 178 and 166 lb
respectively.

CHAPTER 10

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