Biology of Disease

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INDEX

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laxatives 219, 258, 259
LDL cholesterol 404
concentration 404T
direct method 404
LE cells 117
Lea 138
lead 294, 335, 336, 337F
Leb 138
Leber hereditary optic neuropathy
(LHON) 458, 460T
lectin 34, 102B, 429
Legionella pneumophila 46
Leigh syndrome 460T
leishmaniasis 30
leprosy 42, 62, 66
leptin 255B, 488B
Leptospira 43
lesion 4
leucocytes 11F
leucovorin 507
leukapheresis 143M, 153
leukemia 152, 261, 453, 476, 507
leukocyte adhesion deficiency (LAD) 108
leukocyte antigen 129T
leukocytes 74, 75, 76F, 345, 346, 346F, 407,
436B
leukocytosis 108
leukodepleted 142, 143
leukodepleted blood 143, 154C
leukodepletion 128, 129T
leukotrienes 119, 120B, 242
leuprorelin 505
levamisole 64
Levey-Jennings chart 19, 19F
levonorgestrel 193B
Lewis 132T
Lewis antigen 138
Lewis blood group system 138
Lewy bodies 523
Leydig cells 191
life expectancy 515, 519
life span 516
lifestyle 411
lifestyle factors 8
Li-Fraumeni syndrome (LFS) 481B
light chains 81T, 82
light-sensitive rash 292B
limb amputation 66M
limb-girdle dystrophy 468, 468T, 469
lincomycin 62
lincosamide 62
lingual lipase 282, 284
linoleic acid 242
@-linolenic acid (ALA) 242, 485
F-linolenic acid (GLA) 242
lipases 281
lipid 10, 239, 241, 277, 288
lipid metabolism 260
lipid peroxidation 335, 335F
lipofuscin 517, 520, 521F
lipoic acid 338, 338F
lipolysis 177
lipophilic 318
lipopolysaccharides 35, 75, 102T
lipoprotein 402F, 413
concentration 404T


lipase 403
particles, composition of 402, 403T
liposomes 456
liposuction 272
Listeria30, 34, 55B
Listeria monocytogenes 80
lithium 169, 335
live but attenuated microorganism 59
liver 32B, 45, 48, 64, 77, 136, 146T, 177, 254,
263, 277, 278, 279F, 280, 294, 318, 329,
395, 403, 516
autoimmune damage 301
biopsy 302
cancer 301
cirrhosis 299, 329
disease 300, 330
failure 5F, 253B, 302
function 54, 281, 302, 307
lobules 280, 319F
sinusoids 280, 318
transaminases 325
transplant 330
lobar pneumonia 46
lobular carcinoma 501
London 64M
loop of Henle 204F
Lorenzo’s oil 462M, 463
loss of appetite 152
low density lipoprotein particle (LDL) 183,
249, 424, 403, 403F
low ionic strength saline (LISS) 139
lower reference nutrient intake (LRNI) 241
lumen 278
luminal surface 228
lung cancer 5F, 477T, 482T, 484B, 490, 495,
498, 498F, 499
smoking as a risk factor 2, 484B
lung epithelium 227F
lungs 77, 318
exchange capacity 516
luteinizing hormone (LH) 165–6, 191, 194,
196
Lutheran 132T
lycopene 485, 485F, 502
Lyme disease 31, 59
lymph 86, 89
lymph nodes 46, 54, 77, 86, 501, 502
lymphadenopathy 54, 108
lymphadenopathy virus (LAV ) 50B
lymphatic system 31, 37, 46
lymphocyte function tests 102B
lymphocytes 108, 348, 349, 527
lymphocytosis 54
lymphocytotoxicity assay 149
lymphogranuloma venereum 52
lymphoid stem cells 86, 347F
lymphoid tissues 86
lymphoma 50T, 150, 152, 476, 477T, 505T
lymphopenia 267
lysis 135
lysosomal disorders 463
lysosomal hydrolytic enzymes 66M, 463,
464
lysosomal storage diseases (LSDs) 463,
463T, 464, 465, 472
lysosomes 449, 463F, 521F

lysozyme 74, 285
lysyl oxidase 252B

M
M cell 48
MAC (see membrane attack complex) 140
macrocytic anemia 269
macrolide 62
macrolide antibiotic 151
macronutrients 240
macrophage 27, 44, 46, 77–8, 85, 92, 107–8,
136, 141T, 254, 346, 349, 521F
maculopapular skin rash 152
magic bullet therapy 497
magnesium 250
distribution 218, 218F
magnetic resonance imaging (MRI) 54,
161B, 261B, 397, 408, 469, 489, 490,
526B, 526F
major histocompatibility complex (MHC)
antigens 127, 128, 142
Class I MHC proteins 146
Class I gene 147
Class II MHC proteins 146
Class II molecules 148
Class II region 148
MHC molecules 34, 82M
Class I 91F, 92F
Class II 91–3, 91F, 94F
MHC I molecule 147
MHC II protein 147
malabsorption 297, 307, 308, 330, 358, 359,
454, 488B
clinical features 308F
malabsorption of fat 16, 175, 260–2, 284M
malaise 45, 300, 394B
malaria 30, 32B, 59, 144T, 365B, 367, 470
sequencing of genome 32B
symptoms 32B
vaccines 79B
malarial parasite 34, 67B, 138
male reproductive system 189F
malignancies 10, 44M
malignant melanoma 497, 518
malignant tumors 6, 475
Mallory-Weiss tear 287B
malnutrition 8, 293B, 330
laboratory tests 266T
maltase 286
maltose 286
mammary artery 401
mammography 481B, 489, 501
Manchester Blood Centre 142M
manganese deficiency 265
manifestation of disease 4, 5
sign 4
subclinical stage 4
symptom 4
mannitol 333
mannose binding lectin (MBL) 75, 108
deficiency 109
mannose 6-phosphate 463, 464
Mantoux reaction 122
Mantoux test 122F, 123
marasmus 252, 253, 253F, 267, 274
marrow 10, 359F
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