by the Centers for Disease Control and Prevention (CDC)... C. difficile causes an
inflammation of the color and deadly diarrhea.”- “Approximately 29,000 patients died within 30 days of the initial diagnosis of C.
difficile...More than 80 percent of the deaths associated with C. difficile occurred
among Americans aged 65 years or older.” - “1 out of every 5 patients with a healthcare-associated C. difficile infection
experienced a recurrence of the infection and 1 out of every 9 patients aged 65 or
older with a healthcare-associated C. difficile infection died within 30 days of
diagnosis.”
Ceylan, O., Okemen, G. and Ugur, A. (2008). Isolation of soil streptomyces as source
antibiotics active against antibiotic-resistant bacteria. Journal of Biosciences. pg. 73-82.
http://www.ejobios.com/content/2/9/73-82.
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.549.3449&rep=rep1&type=p
df
- “In this work, we have shown that a total of 15 different Streptomycetes isolates
associated with soil have the ability to produce antimicrobial compounds against
microorganisms, especially multiple antibiotic resistant Gram positive and Gram
negative bacteria. Further investigations are needed in order to further determine
the active metabolites of these isolates.”
Chen, M., Yu, Q. and Sun, H. (2013). Novel strategies for the prevention and treatment
of biofilm related infections. International Journal of Molecular Sciences. 14. pg.
18488 -501.
- “Biofilm formation by human bacterial pathogens on implanted medical devices
causes major morbidity and mortality among patients, and leads to billions of
dollars in healthcare cost. Biofilm is a complex bacterial community that is
highly resistant to antibiotics and human immunity.” - “As a result, novel therapeutic solutions other than the conventional antibiotic
therapies are in urgent need...Discovery of alternative approaches to prevent or
treat biofilms...[includes] the molecular mechanism of biofilm formation [and]
modifying the biomaterials used in medical devices.” - “These novel anti-biofilm technologies could eventually lead to anti-biofilm
therapies that are superior to the current antibiotic treatment.”
Choffnes, Eileen R., Relman, David A., Olsen, LeighAnne, Hutton, Rebekah and Mack,
Alison, eds. (2012). Improving food safety through a one health approach: Workshop
summary. The National Academies Press, Washington, DC.
http://www.ncbi.nlm.nih.gov/books/NBK100665/pdf/Bookshelf_NBK100665.pdf