Understanding these factors will ultimately optimize preventive strategies for an
unpredictable future.”- “These determinants can be grouped into 4 categories.”
- “Whether the current epidemic of antimicrobial resistance is sustainable or will
succumb to current efforts to limit its spread will be decided by an interaction of
factors related to microorganisms, host, use patterns of antimicrobial drugs, and
the impact of infection control measures and technologic development.” - “We hope that adding infection control and prudent use of antimicrobial agents
to new drug development will avert the realization of pessimistic predictions
about the future of antimicrobial resistance.” - Unfortunately, by early 2016, we are now facing a worldwide antibiotic
resistance pandemic.
Hawkey, P. M. and Jones, A. M. (2009).The changing epidemiology of resistance.
Journal of Antimicrobial Chemotherapy. 64(Suppl. 1). pg. i3-10.
http://jac.oxfordjournals.org/content/64/suppl_1/i3.long
- “Resistance in Gram-positive bacteria is also widely distributed and increasing,
with the emergence of community-associated methicillin-resistant
Staphylococcus aureus (MRSA) blurring the distinction between hospital and
community strains.” - ”Surveillance data reported high levels of ESBL-producing strains of Klebsiella
pneumoniae and E. coli in Australasia, ranging from <10% in Australia and
Japan to >30% in Singapore and China for K. pneumoniae and from ~11% in
Singapore to 25% in China for E. coli. Subsequent analysis of strains from China
identified CTX-M-14 as the dominant genotype, which has been found
particularly in the Far East but has also spread worldwide.”