Reinert, R., et al. (2007). Antimicrobial susceptibility among organisms from the
Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and
the in vitro activity of tigecycline. Oxford University Press on behalf of the British
Society for Antimicrobial Chemotherapy. 60(5). pg. 1018-29.
http://jac.oxfordjournals.org/content/60/5/1018.long
- “Widespread inappropriate use of antimicrobial agents in the hospital setting has
resulted in the emergence of resistance in nosocomial organisms, and lack of
adherence to hygiene practices has facilitated their dissemination.” - “The key to antimicrobial development has been to design agents that elude the
main bacterial resistance mechanisms. One such agent is tigecycline, a
tetracycline analogue in the new antimicrobial class of glycyclines.” - “The Tigecycline Evaluation and Surveillance Trial (TEST) is a global
multicenter study designed to compare the in vitro activity of tigecycline with
established antimicrobial agents against a range of clinically important
organisms.” - “Surveillance of antimicrobial resistance is essential to understand trends in
resistance so as to develop judicious treatment guidelines and to assess the
effectiveness of interventions. There are a number of international surveillance
studies currently in operation, perhaps the most widely known being The
Surveillance Network (TSN) and SENTRY. TEST covers a large geographic
area, involves a wide range of Gram-positive and Gram-negative organisms and
with 3 years of operation currently contains more than 35,000 isolations in its
database.” - “A comprehensive worldwide survey of anti-microbial susceptibility in so far as
data was available between January and August 2006.” - The study was funded by Wyeth Pharmaceuticals.
Rice, L. (2006). Antimicrobial resistance in gram-positive bacteria. The American
Journal of Medicine. 119(6A). pg. S11-9.
http://www.ncbi.nlm.nih.gov/pubmed/16735146
- “In the United States, approximately 60% of staphylococcal infections in the
intensive care unit are now caused by MRSA, and percentages continue to rise.
Outbreaks of hospital-acquired MRSA (HA-MRSA) are typically the result of
clonal spread by MRSA being transferred from patient to patient, frequently
using healthcare personnel as intermediaries. HA-MRSA strains are generally
multidrug resistant...The mechanisms of methicillin resistance are the same for
CA-MRSA and HA-MRSA.”