- “The problem of multidrug-resistant microbial infection remains a ubiquitous
and complex issue for communities and hospitals. Each decade seems to usher in
a new generation of common bacterial pathogens that have become resistant to
available antibiotics.”
Siegel, R. (2008). Emerging gram-negative antibiotic resistance: Daunting challenges,
declining sensitivities, and dire consequences. Respiratory Care. 53(4).
http://www.ncbi.nlm.nih.gov/pubmed/18364060
- “Emerging antibiotic resistance has created a major public health dilemma,
compounded by a dearth of new antibiotic options. Multidrug-resistant Gram-
negative organisms have received less attention than Gram-positive threats, such
as methicillin-resistant Staphylococcus aureus, but are just as
menacing...Carbapenems, currently the most successful class of antibiotics, are
showing signs of vulnerability.”
Sieradzki, K., et al. (1999). The development of Vancomycin resistance in a patient
with methicillin-resistant Staphylococcus Aureus infection. Massachusetts Medical
Society. 340(7). http://www.nejm.org/doi/full/10.1056/NEJM199902183400704
- “Over the past two decades, vancomycin has been considered the antibiotic of
choice for methicillin-resistant Staphylococcus aureus (MRSA) infections.” - “Recent reports describing the therapeutic failure of vancomycin for MRSA
infections have aroused considerable concern regarding the emergence of MRSA
strains for which there will be no effective therapy.” - “The mechanism of reduced susceptibility in these staphylococcal strains has not
been identified, although data indicate that it is not the same as the vancomycin-
resistance mechanism in enterococcal strains.”
Sieradzki, K., et al. (1999). The development of vancomycin resistance in a patient with
methicillin-resistant staphylococcus aureus infection. New England Journal of
Medicine. 340. Pg. 517-523.
http://www.nejm.org/doi/full/10.1056/NEJM199902183400704
- “Over the past two decades, vancomycin has been considered the antibiotic of
choice for methicillin-resistant Staphylococcus aureus (MRSA) infections.” - “Recent reports describing the therapeutic failure of vancomycin for MRSA
infections have aroused considerable concern regarding the emergence of MRSA
strains for which there will be no effective therapy.”