Long-term risky use of benzodiazepines is
associated with cognitive impairment, other
adverse effects and a high risk of drug
interactions, addiction and withdrawal syndrome
that can be life threatening.^182 Likewise, risky
use of barbiturates, such as butalbital and
phenobarbital, can lead to changes in alertness,
irritability and memory loss.^183 If combined
with certain medications or alcohol, tranquilizers
and sedatives can slow both heart rate and
respiration, which can be fatal.^184
Taking certain controlled prescription drugs
during pregnancy, such as alprazolam (Xanax)
or phenobarbital, may harm the developing
fetus.^185