Science - USA (2022-03-04)

developed, showing zero longitudinal resist- ance down ton= 11. By contrast, the cavity- coupled sample displays deviations from ...

the cyclotron energy is consistent with our model for the scattering because the latter involves the overlap between electronic ...

MOLECULARKNOTS Vernier template synthesis of molecular knots Zoe Ashbridge^1 , Elisabeth Kreidt^1 , Lucian Pirvu^1 , Fredrik Sch ...

fluoride (Et 4 NF), and the resulting demetal- ated knot was isolated by size-exclusion chro- matography to give (L 2 )- 1 in 14 ...

composite knots ( 51 )], which could be covalently captured to yield a trefoil-of-trefoils triskelion knot (Fig. 1C). We postula ...

1038 4 MARCH 2022¥VOL 375 ISSUE 6584 science.orgSCIENCE Fig. 3. Vernier (3:4, strand:metal ion) template synthesis of 12-crossin ...

relate to certain pseudocontact shifts of nuclei located on these surfaces. Nuclei located on the same isosurface experience the ...

the symmetry of the supramolecular Vernier complex. The 1:3 ratio of environments also rules out alternative structures, such as ...

D. V. Kondratuket al.,Angew. Chem. Int. Ed. 51 , 6696–6699 (2012). D. V. Kondratuket al.,Chem. Eur. J. 20 , 12826–12834 (2014). ...

fig. S1). By contrast, heterologous booster vac- cination with mRNA-1273 led to a much larger (86-fold) increase in S-specific s ...

SCIENCEscience.org 4 MARCH 2022¥VOL 375 ISSUE 6584 1043 WT (0.16%) WT S/S-2P cross-reactive (0.84%) Vaccinated A BC pandemicPre- ...

OC43 and HKU1 S proteins at both sampling time points. At the preboost time point, we de- tected significantly elevated serum an ...

donors (geometric mean titers = 1595, 727, and 854 for D614G, Beta, and Delta, respectively) (Fig. 1, H to J). Furthermore, abou ...

vaccination induced a robust expansion of S- specific IgG+B cells in most donors, averaging a fourfold increase over the corresp ...

Last,weassessedtheRBD-andNTD- directed antibodies isolated from both donor cohorts for reactivity with multiple SARS-CoV-2 VOCs ...

CORONAVIRUS Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody Wanchao Yin^1 †, Youwei Xu^1 †, Peiyu ...

whole RBD deviating by <0.4 Å (Fig. 3B and table S3). We did see local differences at the ACE2-RBD interface: The Omicron RBD ...

1050 4 MARCH 2022¥VOL 375 ISSUE 6584 science.orgSCIENCE Fig. 2. Structure of the ACE2-bound Omicron spike trimer complex and epi ...

the WT SARS-CoV-2 in cell-based models and in a rhesus monkey model ( 20 ). JMB2002 has completed a phase 1 clinical trial in he ...

RBD-RBD interaction and extra interactions in the ACE2-RBD interface, both of which con- tribute to the higher affinity of ACE2 ...