SCIENCEscience.org 4 MARCH 2022¥VOL 375 ISSUE 6584 1057
Fig. 4.Bend3deletion leads to premature activation of highly occupied
bivalent genes during differentiation.(A) PCA results of transcriptomes in
WT,Bend3Het, andBend3KO ESCs and EBs at d1, d2, and d3. Two clones were
used for each genotype. (B) Scatter plots showing gene expression levels
between WT andBend3KO ESCs and EBs at d1, d2, and d3 during
differentiation. Significantly dysregulated (fold change > 2; adjustedP< 0.05RESEARCH | REPORTS