Special Operations Forces Medical Handbook

A-29

Appendices: Organism/Antibiotic Chart

Developed by LTC Glenn Wortmann, MC, USA, LTC Duane Hospenthal, MC, USA & LCDR (sel) Edward

Moldenhauer, MSC, USN

Infecting Organism Medication of Choice Alternatives

I. AEROBIC BACTERIA

A. Gram-positive Cocci

1. Staphylococi
   a. S. aureus (methicillin-sensitive) PRP, Cephalosporin Vanocomycin, Clindamycin,
   (1st generation) Sulfa-trimethaprim
   b. S. aureus (methicillin-resistant) Vancomycin Clindamycin, Sulfa-trimethoprim,
   Linezolid, Quinupristin-dalfopristin
   c. S. epidermidis Vancomycin Linezolid, Quinupristin-dalfopristin


2. Streptococci
   a. Streptoccocus, Group A, B, C, G, Penicillin G or V Cephalosporin (1st generation),
   S. viridans and penicillin-sensitive Vancomycin, Clindamycin,
   S. pneumoniae Erythromycin, Azithromycin
   b. S. pneumoniae with high level Vancomycin Levofloxacin
   penicillin-resistance
   c. Enterococci Ampicillin and Gentamicin Vancomycin and Gentamicin

B. Gram-positive Bacilli

1. Bacillus anthracis Penicillin or Ciprofloxacin Doxycycline


2. Corynebacterium diphtheriae Erythromycin and Antitoxin Clindamycin, Penicillin G


3. Listeria monocytogenes Ampicillin or Penicillin Sulfa-trimethoprim

C. Gram-negative Cocci

1. Neisseria gonorrhoeae Ceftriaxone or Cefixime
   Fluoroquinolone


2. Neisseria meningitidis Penicillin G or V Ceftriaxone


3. Moraxella catarrhalis Sulfa-trimethoprim, Azithromycin, doxycycline
   Amoxicillin-clavulanate

D. Gram-negative Bacilli

1. Escherichia coli Sulfa-trimethoprim Cephalosporin (3rd generation),
   (if sensitive) fluoroquinolone


2. Enterobacter species Imipenem Fluoroquinolone, Cephalosporin
   (3rd generation)


3. Klebsiella species Imipenem Fluoroquinolone, Cephalosporin
   (3rd generation)


4. Pseudomonas aeruginosa APP Ceftazidime


5. Proteus species APP Cephalosporin (3rd generation),
   fluoroquinolone


6. Serratia marcescens Cephalosporin (3rd Imipenem, Fluoroquinolone
   generation)


7. Salmonella typhi Ceftriaxone or Sulfa-trimethoprim
   fluoroquinolone


8. Haemophilus influenzae Ceftriaxone or Azithromycin, doxycycline,
   fluoroquinolone Amoxacillin-clavulanic acid


9. Haemophilus ducreyi Ceftriaxone or Amoxicillin-clavulanic acid, Azithromycin,
   fluoroquinolone Erythromycin