Organic Chemistry

Introduction 1205

Proprietary name Generic name Structure Use

Hydrocodone Hydrocodone Analgesic

with APAP with APAP

Atorvastatin Statin

(cholesterol-reducing drug)

Conjugated Hormone replacement therapy

estrogens

Levothyroxine Treatment of

hypothyroidism

Azithromycin Antibiotic

Cl

O

COOH

H 2 NSO 2

NHCH 2

Lasix Furosimide Diuretic



Zithromax®

Synthroid®

Premarin®

Lipitor®

Table 30.1 The Most Widely Prescribed Drugs in the United States

OH

O

CH 3 CNH

NCH 3

CH 3 O O O

(CH 3 ) 2 CH

OH OH

O

F

HOC

O

NH C

N

H 3 C

O

HO

Tenormin Atenolol H 2 NCCH 2 OCH 2 CHCH 2 NHCH(CH 3 ) 2

β-adrenergic

blocking agent

(antiarrhythmic,

antihypertensive)

O

OH

HO O CH 2 CHCO−Na+

I

I

I

I

NH 2

O

N

O

O

H 3 CCH 3

CH 3

CH 3

CH 3

CH 3

CH (^3) CH 3
CH 3 CH 2
H 3 C
H 3 C
H 3 C
CH 3
O
HO
HO
N
O
OH
OH
OH
O OCH 3
O
BRUI30-1204_ 1228r2 18-03-2003 8:55 AM Page 1205