tamine, pyrilamine (Mepyramine). In 1947 he went to
Rome to organize a laboratory of therapeutic chemistry
and became an Italian citizen. He became the labora-
tory’s chief at the Istituto Superiore di Sanità, Rome.
Seeking a substitute for curare, a muscle relaxant, for
anesthesia, he discovered gallamine (trade name
Flaxedil), a neuromuscular blocking agent used today as
a muscle relaxant in the administration of anesthesia.
He and his wife Filomena Nitti published two
important books: Structure chimique et activité phar-
macodynamique des médicaments du système nerveux
végétatif(The chemical structure and pharmacodynamic
activity of drugs of the vegetative nervous system) in
1948 and, with G. B. Marini-Bettòlo, Curare and
Curare-like Agentsin 1959. In 1957 he was awarded
the Nobel Prize in physiology or medicine for his dis-
covery relating to synthetic compounds that blocked the
effects of certain substances occurring in the body, espe-
cially in its blood vessels and skeletal muscles.
Bovet published more than 300 papers and
received numerous awards. He served as the head of
the psychobiology and psychopharmacology laboratory
of the National Research Council (Rome) from 1969
until 1971, when he became professor of psychobiol-
ogy at the University of Rome (1971–82). He died on
April 8, 1992, in Rome.
Boyle’s law The volume of a given mass of gas held
at constant temperature is inversely proportional to
the pressure under which it is measured. Articulated as
PV = k.
Bragg equation An equation (nλ= 2dsinθ) in which:n= order of diffracted beam
λ= wavelength of X-ray beam (in angstroms)
d= distance between diffracting planes (in
angstroms)
θ= angle between incident X rays and the
diffracting planes (in degrees)Discovered by Lawrence Bragg in 1912, the equa-
tion deduces the angles at which X rays scatter from a
crystal to the spacing between the layers of molecules.brain imaging In addition to MAGNETIC RESONANCE
IMAGING, which is based on the brain’s absorption of
electromagnetic radiation, brain images can be acquired
by scintillation counting (scintigraphy) of radiation emit-
ted from radioactive nuclei that have crossed the
blood–brain barrier. The introduction of radionuclides
into brain tissue is accomplished with the use of specific
99mT c(V) COMPLEXes with lipophilic ligands.
See alsoIMAGING.Bredt’s rule A double bond cannot be placed with
one terminus at the bridgehead of a bridged ring sys-
tem unless the rings are large enough to accommodate
the double bond without excessive STRAIN. For exam-
ple, while bicyclo[2.2.1]hept-1-ene is only capable of
existence as a TRANSIENT SPECIES, its higher homo-
logues having a double bond at the bridgehead position
have been isolated. For example:breeder reactor A nuclear reactor that produces and
consumes fissionable fuel but creates more fissionable
nuclear fuel than it consumes. The fission chain reac-
tion is sustained by thermal neutrons.breeder reactor 33The volume of a given mass of gas varies inversely with its
pressure at constant temperature.