Table 2.1 lists the model parameters
and the fractional transfer rates (Li,jfrom
compartment j to i). The fractional standard
deviation of the parameters ranges from 5
to 50% and, in general, L2,1, L1,2and L0,1or
L0,3are solved with a higher precision than40 J.A. Rathmacher
1.0000.1000.0100.001Tracer to tracee ratio0 1 2 3 4 5Cattle, human and dog model
Observed Calculated(A)Time (min 1000)0.1000.0100.001Tracer to tracee ratio0 1 2 3 4 5Sheep modelObserved Calculated(B)Time (min 1000)1.0000.1000.0100.001Tracer to tracee ratio0 1 2 3 4 5 6Swine modelObserved Calculated(C)Time (min 1000)Fig. 2.10.Disappearance of tracer, 3-[^2 H 3 -methyl]methylhistidine, as the ratio of 3-[^2 H 3 -methyl]methylhisti-
dine to 3-methylhistidine in plasma as described by a three-compartment model of 3-methylhistidine (see