L3,2and L2,3. Table 2.2 compares the com-
partment masses and mass transfer rates
between compartments for each species.
Also listed is the de novoproduction rateMeasurement and Significance of Protein Turnover 41Tracer(A) Cattle, dog and human model1
Extracellular
fluid2
Tissue
pool3
Tissue
poolUrine 3MHSkeletal
muscle
de
novoTracer(B) Sheep modelExtracellular
fluidTissue
poolTissue
poolUrine 3MHSkeletal
muscle
de
novoBalenineTracer(C) Swine model1
Extracellular
fluid2
Tissue
pool3
Tissue
poolSkeletal
muscle
de
novoBalenineFig. 2.11.Schematic of the three-compartment models used to analyse the kinetics of distribution, metabolism
and de novoproduction of 3-methylhistidine (3MH). The tracer, 3-[^2 H 3 -methyl]methylhistidine (D 3 -3MH), was
injected into compartment 1. Sampling was performed from compartment 1. De novoproduction of 3MH
and the exit from the system are dependent on the physiology of the species.