Common Serum Protein Electrophoresis
Patterns
Clinical Chemistry Review 90
CONDITION PATTERN
Normal
Acute inflammation ↑alpha-1 & alpha-2
Chronic infection ↑alpha-1, alpha-2, & gamma
Cirrhosis Polyclonal ↑(all fractions) in gamma with beta-gamma bridging
Monoclonal gammopathy Sharp ↑in 1 immunoglobulin (“M spike”). ↓in other fractions
Albumin
Alpha 1
Alpha 2
Beta
Gamma
Serum protein electrophoresis showing patterns of normal serum. (From
Ciesla B. Hematology in Practice, 2nd ed. Philadelphia: FA Davis; 2012:212.)
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