Changes During Cell Maturation Hematology Review 294
CHARACTERISTIC CHANGE(S) WITH MATURATION
Size Becomes smaller.N:C ratio Becomes smaller.Cytoplasm Less basophilic due to loss of RNA. Granulocytes produce granules. Erythrocytes become pink due to Hgb
production.Nucleus Becomes smaller. Nuclear chromatin condenses. Nucleoli disappear. In granulocytic series, nucleus indents,
then segments. In erythrocytic series, nucleus is extruded.N:C ratio = nucleus to cytoplasm ratio