Hemoglobinopathy Versus Thalassemia Hematology Review 307
HEMOGLOBINOPATHY THALASSEMIA
Abnormality Qualitative abnormality. Abnormality in amino acid Quantitative abnormality. Amino acid sequence of globin
sequence of globin chain, not in amount of globin chains is normal, but underproduction of 1 or more globin
produced. chains.Examples Sickle cell anemia & trait, hemoglobin C disease & trait. b-thalassemia major & minor.Note: Some hematologists refer to all qualitative & quantitative hemoglobin abnormalities as hemoglobinopathies.