Quick Review Cards for Medical Laboratory Science

Normocytic Anemiascontinued Hematology Review 309

Hemoglobin C

trait (AC)

SC disease (SC)

Hereditary

spherocytosis

Autoimmune

hemolytic anemia

HEMOGLOBIN

ANEMIA ETIOLOGY BLOOD SMEAR ELECTROPHORESIS OTHER

Inheritance of gene for

Hgb C from 1 parent.

Inheritance of 1 sickle cell

gene & 1 Hgb C gene.

Defect of cell membrane.

Autoantibodies.

Many target cells.

Many target cells. Folded &

boat-shaped cells, occa-

sional SC crystals (finger-like

projections, “Washington

Monument” crystals).

Spherocytes, polychromasia.

Polychromasia, sphero-

cytes, nRBCs.

60%–70% A,

30%–40% C

>S than C, normal

to 7% F, no A

Normal

Normal

Pos solubility test. Mild to

moderate anemia.

MCHC usually >36 g/dL.

↑retics, ↑osmotic fragility.

↑retics, ↑indirect bili,

↓haptoglobin, pos DAT.

N = normal, nRBCs = nucleated red blood cells, DAT = direct antiglobulin test.