Quick Review Cards for Medical Laboratory Science

Classification of Hematopoietic Neoplasms Hematology Review 320

FRENCH-AMERICAN-BRITISH (FAB) WORLD HEALTH ORGANIZATION (WHO), 2008

Criteria Morphology, cytochemistry, immunophenotyping Morphology, cytochemistry, immunophenotyping,

cytogenetics, clinical features

Major groups Myeloproliferative disorders (MPD) Myeloproliferative neoplasms (MPN)

Myeloplastic syndromes (MDS) Myeloid & lymphoid neoplasms associated with eosinophilia

Acute leukemias (AL) & abnormalities of PDGFRA, PDGFRB, or FGFR1*

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

Myelodysplastic syndromes (MDS)

Acute myeloid leukemia (AML) & related neoplasms

Acute leukemias of ambiguous lineage

B-lymphoblastic leukemia/lymphoma

T-lymphoblastic leukemia/lymphoma

Criteria for ≥30% blasts ≥20% blasts

diagnosis of AML

Use 1st system. Still used by some but being Widely used

replaced by WHO.

*PDGFRA, PDGFRB,& FGFR1are genes that code for production of platelet-derived growth factor receptor (alpha & beta types) & fibroblast growth factor receptor 1.
Abnormalities in these genes are a factor in selection of drug therapy.