Plasma Cell Disorders Hematology Review 326
DISORDER KEY CHARACTERISTICS
Multiple myeloma Malignant plasma cells in marrow. Normocytic, normochromic anemia. Rouleaux on blood smear.
↑ESR due to ↑globulins. M spike on serum protein electrophoresis (monoclonal gammopathy).
May have Bence Jones proteinuria. Lytic bone disease.Plasma cell leukemia Form of multiple myeloma. Plasma cells in peripheral blood. Pancytopenia. Rouleaux. Monoclonal
gammopathy.Waldenström’s macroglobulinemia Malignant lymphocyte–plasma cell proliferative disorder. Monoclonal gammopathy due to ↑IgM.
Rare plasmacytoid lymphocytes or plasma cells on peripheral smear. Rouleaux. May have Bence
Jones proteinuria & cryoglobulins.ESR = erythrocyte sedimentation rate.