Quantitative Platelet Disorders Hematology Review 342
DISORDER EXPLANATION CLINICAL MANIFESTATIONS LAB TESTS
Thrombocytopenia
Primary thrombocytosis
Secondary or reactive
thrombocytosis
↓production (e.g., aplastic ane-
mia, myelodysplastic syn-
dromes), ↑destruction (e.g.,
immune thrombocytopenic pur-
pura, drugs, DIC, mechanical
destruction by artificial heart
valves), splenic sequestration,
massive transfusion (dilution
effect)
Unregulated production of
megakaryocytes in bone
marrow, e.g., essential thrombo-
cythemia, other myeloprolifera-
tive disorders
↑PLT due to another condition,
e.g., hemorrhage, surgery,
splenectomy
<30 ¥ 109 /L: petechiae, menorrha-
gia, spontaneous bruising.
<10 ¥ 109 /L: severe spontaneous
bleeding
Thrombosis or hemorrhage
Thrombosis or hemorrhage
infrequent
PLT <150 ¥ 109 /L
PLT usually >1,000 ¥ 109 /L.
Platelet aggregation may
be abnormal
PLT >450 ¥ 109 /L but
usually <1,000 ¥ 109 /L
