Quick Review Cards for Medical Laboratory Science

Coagulation Factors Hematology Review 345

NAME PATHWAY INHERITED DEFICIENCY OTHER

I

II

III

IV

V

VII

VIII

Fibrinogen

Prothrombin

Tissue factor (TF)

Ca2+

Labile factor (proaccelerin)

Stable factor (proconvertin)

Antihemophilic factor

I, E, C

I, E, C

E

I, E, C

I, E, C

E

I

Rare

Rare

Rare

Rare

Common (hemophilia A)

Converted to fibrin by thrombin.

Precursor of thrombin.

Phospholipid released from

injured vessel wall. Not normally

in blood.

Bound by anticoagulant sodium

citrate. In assays using citrated

plasma, must be supplied by

reagents.

Deteriorates rapidly.

Circulates in association with von

Willebrand factor (VWF). VIII:

C = coagulant portion. Extremely

labile.

continued...