Summary of Coagulation Factors Hematology Review 348
FACTORS EXPLANATION
Contact group
Prothrombin group
Fibrinogen group
Factors in extrinsic pathway
Factors in intrinsic pathway
Factors in common pathway
Extrinsic tenase complex
Intrinsic tenase complex
Prothrombinase complex
Factor VIII complex
Produced in liver
PK, HMWK, XII, XI
II, VII, IX, X
I, V, VIII, XIII
TF, VII
PK, HMWK, XII, XI, IX, VIII
X, V, II, I
VIIa/TF
IXa/VIIIa
Xa/Va
VIII:C & von Willebrand factor (VWF)
All
Factors involved in initiation of intrinsic pathway.
Vitamin K–dependent factors.
Factors acted on by thrombin (V, VIII, & XIII are acti-
vated; I is converted to fibrin). All are high molecular
weight proteins.
Acts on X.
Acts on X.
Acts on prothrombin.
VIII:C is the procoagulant; VWF is the carrier protein.
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