Quick Review Cards for Medical Laboratory Science

Cell-Based Model of Hemostasis Hematology Review 352

Xa•Va

VIIa•

TF

Tissue-factor bearing

cell (fibroblast)

TF

VIIa•

IXa•VIIIa

Xa

Va•

(Small amount

of thrombin)

Free vWF

VIIIa

VIIIa

• vWF

1. Initiation

3. Propagation

2. Amplification

Platelet

Va

XIa

XI

IIa

II

II

IIa

(Large amounts

of thrombin)

X

X

IXa

IX

IX

XIa

Activated platelet

(From Harmening DM. Clinical

Hematology and Fundamentals

of Hemostasis, 5th ed. Philadel-

phia: FA Davis; 2009:569.)