Most Common Inherited Coagulation
Disorders
Hematology Review 356
DISEASE DEFICIENCY CLINICAL FINDINGS LABORATORY FINDINGS OTHER
Von Willebrand
disease
Hemophilia A
Hemophilia B
(Christmas
disease)
VWF
Factor VIII
Factor IX
Mucocutaneous bleed-
ing ranging from mild
to severe
Varies from asympto-
matic to crippling bleed-
ing into joints, muscles,
& fatal intracranial
hemorrhage
Same as hemophilia A
PLT: N
Closure time (PFA): N or ↑
Platelet aggregation: abnormal
with ristocetin
PT: N
APTT: N or ↑
Factor VIII: N or ↓
VWF:Ag: ↓
PLT: N
PT: N
APTT: ↑
Factor VIII: ↓
PLT: N
PT: N
APTT: ↑
Factor IX: ↓
Most common inherited
bleeding disorder. Autoso-
mal dominant. Both sexes
affected. Plts can’t adhere
to collagen to form plt plug.
Lab results vary.
2nd most common inher-
ited bleeding disorder.
Sex-linked recessive. Occurs
primarily in males. Mothers
are carriers.
Sex-linked recessive.
