Acquired Factor Deficiencies Hematology Review 357
CONDITION EXPLANATION
Liver disease Coagulation proteins are synthesized in liver.
Vitamin K deficiency Vitamin K is needed for synthesis of II, VII, IX, X.
Disseminated intravascular coagulation (DIC) Uncontrolled formation & lysis of fibrin in blood vessels. Fibrinogen, II, V, VIII, XIII, & plts
are consumed.
Primary fibrinolysis (fibrinogenolysis) Plasminogen activated to plasmin, degrades fibrinogen, V, VIII, XIII. No fibrin formation.
Acquired inhibitors (circulating anticoagulants) Antibodies against coagulation factors. Inhibitors to VIII & IX are most common & usually
in pts who have received replacement therapy for hemophilia A or B. Occasionally associ-
ated with other diseases or in normal individuals.