Quick Review Cards for Medical Laboratory Science

Immunoglobulin (Ig) Structurecontinued Immunology Review 382

Light chain

hypervariable

regions

Intrachain

disulfide bonds

Interchain

disulfide bonds

Fab

Fc

Amino terminal

Carboxy terminal

Antigen

binding

Biological

activity

mediation

Heavy chain

hypervariable

regions

Light chain

Heavy chain

Hinge region

Complement binding region

V

L

VH

C

L

C

H 1

C

H2C

H 3

Carbohydrate

Structure of the basic immunoglobulin unit. VH = variable region heavy chain; VL = variable region light chain; CH = constant
region heavy chain; CL = constant region light chain. (From Harmening DM. Clinical Hematology and Fundamentals of Hemostasis, 5th ed.
Philadelphia: FA Davis; 2009:502.)