Quick Review Cards for Medical Laboratory Science

Leukocyte Reduction (Leukoreduction) Immunohematology Review 432

Purpose

WBCs

Methods

To ↓WBCs to ↓febrile nonhemolytic transfusion reactions, transmission of CMV, & HLA alloimmunization

<5 ¥ 106

• By apheresis processing


• By filtration during manufacture of components or after storage. Prestorage leukocyte reduction is most effective.
  WBCs removed before they release cytokines


• Use of filter during infusion