Acute Immunologic Transfusion
Reactions*continued
Immunohematology Review 474
TYPE CLINICAL SIGNS CAUSE LABORATORY FINDINGS OTHER
Transfusion-
related acute
lung injury
(TRALI)*Occurring <24 hr after tf.
Most common cause of tf-related
deaths in U.S. Related to infusion of
plasma. All components have been
implicated. Reduced use of plasma
from female donors appears to be
reducing TRALI fatalities.Unknown. Possibly
donor abs to WBC agsFever, chills, cough-
ing, respiratory
distress, fluid in
lungs, ↓BP within
6 hr of tf. Life-
threatening.None