Dextrorphan 117produced offspring having lower weight, delays in maturation, and abnormal
swimming behavior. Whether the drug passes into a human fetus or the milk
supply of a nursing mother is unknown.
Additional scientific information may be found in:
Aylward, M., et al. “Dextromethorphan and Codeine: Comparison of Plasma Kinet-
ics and Antitussive Effects.”European Journal of Respiratory Diseases65 (1984):
283–91.
Dematteis, M., G. Lallement, and M. Mallaret. “Dextromethorphan and Dextrorphan
in Rats: Common Antitussives—Different Behavioural Profiles.”Fundamental
and Clinical Pharmacology12 (1998): 526–37.
“Safety, Tolerability and Pharmacokinetics of the N-Methyl-D-Asparate Antagonist Ro-
01-6794/706 in Patients with Acute Ischemic Stroke.”Annals of the New York
Academy of Sciences765 (1995): 249–61, 298.
Schutz, C.G., and M. Soyka. “Dextromethorphan Challenge in Alcohol-Dependent Pa-
tients and Controls.” With reply by Drystal and Petrakis.Archives of General
Psychiatry57 (2000): 291–92.
Szekely, J.I., L.G. Sharpe, and J.H. Jaffe. “Induction of Phencyclidine-Like Behavior in
Rats by Dextrorphan But Not Dextromethorphan.”Pharmacology, Biochemistry,
and Behavior40 (1991): 381–86.