The Encyclopedia of ADDICTIVE DRUGS

(Greg DeLong) #1
Ketobemidone 215

physical well-being is typical among individuals engaged in self-destruction.
A study of ketobemidone overdose deaths in Denmark was revealing in that
respect as well; victims often had bloodalcohollevels that would be fatal in
themselves.
Drug interactions.A study comparing commercial intravenous pharmaceu-
tical formats found morphine to be only half as strong as a combination prod-
uct containing one part ketobemidone and five parts of a drug called A29.
The latter drug is used to fight spasms. Experiments with rats and mice in-
dicate that A29 boosts ketobemidone’s pain-relieving effect, so the human
research comparing the combination to morphine does not mean that keto-
bemidone alone is stronger than morphine. The same study did find, however,
that when doses were adjusted for equivalent strength, the ketobemidone-A29
combination was still more effective at pain relief than morphine.
Cancer.Not enough scientific information to report.
Pregnancy.The drug passes into human milk. Based on a small number of
cases involving 5,000 micrograms of ketobemidone given during childbirth,
one study estimated that breast-fed infants would receive under 2 micrograms
of ketobemidone from their first day’s milk.
Additional scientific information may be found in:


Kjaer, M., et al. “Bioavailability and Analgesic Effect of Sustained Release Cetobemi-
done Capsules in Cancer Patients with Chronic Pain of Malignant Origin.”Acta
Oncologica(Stockholm, Sweden) 31 (1992): 577–83.
Ohqvist, G., et al. “A Comparison between Morphine, Meperidine and Ketobemidone
in Continuous Intravenous Infusion for Postoperative Relief.”Acta Anaesthesiol-
ogica Scandinavica35 (1991): 44–48.
Steentoft, A., and K. Worm. “Cases of Fatal Intoxication with Ketogan.”Journal—Fo-
rensic Science Society34 (July–September 1994): 181–85.
Wolff, T., et al. “Analgesic Treatment in Acute Myocardial Infarction. A Double-Blind
Comparison of Ketobemidonethe Spasmolytic A29 (Ketogan) and Morphine.”
Acta Medica Scandinavica223 (1988): 423–30.

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