Triazolam 429romycin interfere with the body’s use of triazolam. In rat experiments alcohol
increased triazolam levels in the brain even though blood levels were virtually
unaffected. In human experiments some researchers have concluded that al-
cohol boosts some triazolam effects, but other researchers feel that the length-
ening and deepening of triazolam actions after drinking alcohol simply mean
that both substances have similar effects, not that the two drugs are interact-
ing. Regardless, combining the two can be fatal.
Cancer.A two-year triazolam experiment with mice using up to 4,000 times
the normal human dose yielded no sign that the drug causes cancer.
Pregnancy.Triazolam is not recommended for pregnant women. A case
report tells of a full-term pregnant woman who took 100 times the normal
dose of triazolam plus alcohol, arrived at a hospital unconscious, and deliv-
ered a normal-seeming infant—an exceptional case, however, as lighter tria-
zolam amounts have proved fatal.
In rat studies triazolam passes into milk of nursing rodents. The drug’s level
in rat milk is about 70% of levels in the maternal rat’s blood.
Additional scientific information may be found in:
Ghaeli, P., R.L. Dufresne, and C.A. Stoukides. “Triazolam Treatment Controversy.”
Annals of Pharmacotherapy28 (1994): 1038–40.
Griffiths, R.R., et al. “Relative Abuse Liability of Triazolam: Experimental Assessment
in Animals and Humans.”Neuroscience and Biobehavioral Reviews9 (1985):
133–51.
Klett, C.J. “Review of Triazolam Data.”Journal of Clinical Psychiatry53 (1992, Suppl.):
61–67.
Pakes, G.E., et al. “Triazolam: A Review of Its Pharmacological Properties and Ther-
apeutic Efficacy in Patients with Insomnia.”Drugs22 (1981): 81–110.
Perry, P.J., and D.A. Smith. “Triazolam—Never-Ending Story.”DICP: The Annals of
Pharmacotherapy25 (1991): 1263–64.
Rothschild, A.J. “Disinhibition, Amnestic Reactions, and Other Adverse Reactions Sec-
ondary to Triazolam: A Review of the Literature.”Journal of Clinical Psychiatry
53 (1992, Suppl.): 69–79.
Rush, C.R., et al. “Acute Effects of Triazolam and Lorazepam on Human Learning,
Performance and Subject Ratings.”Journal of Pharmacology and Experimental Ther-
apeutics264 (1993): 1218–26.
Schneider, P.J., and P.J. Perry. “Triazolam—An ‘Abused Drug’ by the Lay Press?”
DICP: The Annals of Pharmacotherapy24 (1990): 389–92.
Spinweber, C.L., and L.C. Johnson. “Effects of Triazolam (0.5 Mg) on Sleep, Perfor-
mance, Memory, and Arousal Threshold.”Psychopharmacology76 (1982): 5–12.