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H4 histamine receptor—Found primarily in bone marrow and white blood cells.
It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus,
tonsils, and trachea. H4 Receptors mediate movement and calcium mobilization
of Mast Cells.
Histamine produces larger pores in the blood vessel walls as the first step in
launching an inflammatory response. The increased blood vessel porosity improves
brain nutrition in times of emergency, when high performance is needed for
survival. The release of histamine in the brain and the consequent improvement
of blood supply is probably one of the main reasons for the increased sensory
and extrasensory perception during kundalini. Brain nutrition and oxygen supply
would be greatly enhanced by the dilated and porous blood vessels, opening up
latent capacities. The release of histamine in the brain, even by itself, would lead to
some expansion of consciousness, but it is just one factor among many that occur
during peak events. Histamine release during peak events would synergize and
amplify the effects of all other hormonal, neurochemical and nutritional agents.
Histamine release is probably most significant during the periods of panic
attack when hypervigilance is at its peak. Histamine contributes to hypervigilance,
because histaminergic cells in the brain promote the most “wakeful” firing pattern.
In fact a sudden rush of histamine in the brain could contribute to a schizophrenic
episode. Histamine also features in the panic events by causing a closing of the
airways in the lungs. When released in the lungs, histamine causes the airways to
swell shut in an attempt to close the door on offending allergens and keep them
out. Thus panic attack periods during kundalini are known for the sense of weight
or contraction on the lungs. As a consequence the sense of suffocation and lack of
oxygen will force the individual out of the house for long walks accompanied by
deep breathing.
Heat—Research on the ability to withstand heat stress identified histamine
receptors as contributing to increased blood flow during heat stress, but only the
H1 receptor was involved in skin blood flow changes.
sleep—It has been shown that histaminergic cells have the most “wakeful” firing
pattern of any neuronal type. They fire rapidly during waking, and completely
stop firing during sleep. The cell bodies of neurons which release histamine as
a neurotransmitter are found in the posterior hypothalamus. From here, these
histaminergic neurons project throughout the brain, to the cortex through the
medial forebrain bundle. Antihistamines, that is substances that block the H1
histamine receptors improve sleep. Likewise, destruction of histamine releasing
neurons, or inhibition of histamine synthesis leads to an inability to maintain
vigilance. Finally, H3 receptor antagonists (which stimulate histamine release)
increase wakefulness.
sex—In sexual arousal Histamine is released from mast cells in the genitals, and
histamine release in the sex flush in women. The female orgasm can be facilitated
by supplemental folic acid along with niacin, which will increase histamine release.
Conversely, men with high histamine levels may suffer from premature ejaculations
through amplified sensitivity.