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and subsequent oxidant induced loss of mitochondrial function was shown to
precipitate programmed cell death or apoptosis, since GSH is the major defense
against the endogenously produced free radicals. seizures/kindling may result
from glutathione peroxidase deficiency. Selenium is necessary to the formation of
GSH, and so selenium deficiency maybe an important factor in the promotion of
seizures and subsequent neuronal damage.
The 5-carbon sugar D-ribose is an energy producing ATP substrate formed
in the body from glucose. Ribose is a component of RNA and DNA and also
necessary for the manufacture of ATP. Mitochondria utilize two methods for
building or conserving cyclic nucleotides like ATP, ADP, and AMP. The longer
pathway where ATP is made “from scratch,” starting with ribose, and there is the
faster “salvage” pathway, in which the mitochondria “pick up the pieces” of ATP
metabolites to form new ATP. Ribose enables cells to quickly and efficiently recycle
the end products formed by the breakdown of ATP to form new ATP molecules.
There are no foods able to provide enough ribose to rapidly restore ribose levels,
should the need arise during exercising, working, or during a heart attack, stroke
or kundalini. So D-Ribose maybe an essential supplement to take especially during
the down-cycles to prevent enervation and excessive apoptosis.
creatine is synthesized in the body from three amino acids: glycine, arginine,
and methionine. It is involved in energy metabolism as a muscle fuel through its
role of regenerating ATP from ADP. Creatine phosphate serves as a reservoir of
high-energy phosphate bonds required to rephosphorylate ADP into ATP. The
resynthesize ATP at required rate improves endurance and available energy during
exercise or excessive expenditure like kundalini awakenings. To prevent fatigue and
excessive catabolic breakdown from lack of ATP production ribose and creatine
should be taken around the clock during awakening.
Aging appears to be in good part due to the oxidants produced as by-products
of normal metabolism by mitochondria. Age related decline in the function of
mitochondria is relieved by the supplementation of alpha lipoic acid and l-
carnitine. Research found that the enzyme carnitine acetyltransferase is less active
in old rats. Supplementation with a combination of acetyl-L-carnitine and alpha-
lipoic acid restored the enzyme’s activity nearly to that found in young rats. The
acetyl-L-carnitine protects the enzyme and the higher levels are enabling the protein
to work, while alpha-lipoic acid reduces free radicals. The two together reverse the
effects of aging on mitochondria. Carnitine also helps protect the mitochondria
membranes and assists in the transport of fatty acids into the mitochondria. Since
the mitochondrion provide the energy source (ATP) for cell function, through
mitochondrial oxidative metabolism of glucose, interference with the mitochondrial
electron transport system can have fatal consequences to the cell. The high free
radical load during metamorphosis may put such a high demand on the body’s
glutathione production that there is insufficient to protect against apoptosis. Alpha
Lipoic Acid maybe more effective than NAC in preventing apoptosis.
Charged phospholipids in the cell membranes play a crucial role in apoptosis.
There is increasing evidence that the arrangement of polar lipids in the membrane