Eicosanoids
ecstasY anD neUroinHiBition
Because of the ubiquitous, body-wide “cellular” ecstasy that kundalini
produces I am playing with the idea that the pervasive cellular bliss could be due
to anandamide, an opioid neuroinhibitor produced from the arachidonic acid in
the fat of cell membranes. Levels of arachidonic acid must be increased by the extra
free radicals produced during kundalini awakening—from the extra biophoton
production, increased stress glucocorticoids, the increased metabolism, apoptosis,
catabolism of tissues and liberation of extra toxin stores especially from fat cells
being used up in the energy generation method of catabolic-gluconeogenesis.
The picture that is arising is that the bliss of kundalini is associated with the
neuroinhibiting opioids systems (endorphin, enkephalin, dynorphin). And that the
increase in light, free radical generation, and catabolic energy generation of lipolysis
and gluconeogenesis actually produce inflammatory agents like arachidonic acid and
excitatory neurochemicals that keep the hyperactivation of the HPA axis at high
rev in a snowball feedback mechanism. Kundalini thus represent a self-consuming,
self-conflagration that results in a renewal of tissues using the building blocks of
the old. (Lipolysis is breakdown of fat stored in fat cells and gluconeogenesis glucose
from non-sugar carbon substrates like pyruvate, lactate, glycerol, and amino acids-
alanine and glutamine).
To help compensate for the excitotoxicity of glutamate and other activating
neurotransmitters (catecholamines) associated with kundalini activation, Robert
Sapolsky says that endogenous neuronal defenses include substances such as
adenosine, GABA and taurine. Other neuroinhibitors include the opiates Beta-
endorphin which has 40 times the inhibitory powers of morphine and Dynorphine.
Dynorphine is an endorphin the body makes that is 700 times more potent than
morphine. It is produced at death and will wipe out any conceivable sensation of
pain in the brain. Dynorphines are not produced only at death but is probably
produced along with DMT at birth, as well as other extreme events. The extreme
stress of battle also causes catecholamine and Dynorphine production in soldiers
and the analgesic effect of acupuncture is based on Dynorphine. Dynorphines
might also be produced during sex and most definitely during inner conjunctions
as part of the chemistry of ecstatic paralysis.
The opioid precursor polypeptide Pro-opiomelanocortin (Pomc) is
synthesized by the pituitary gland, the hypothalamus and brainstem. POMC can
be cleaved enzymatically into several peptides including adrenocorticotrophic
hormone (ACTH) and B-endorphin. Pro-opiomelanocortin might be one of the
main peptides involved in kundalini because it is produced in the right places
for the stimulation of overall activation and because it is a precursor to both
endorphins and stimulation of the HPA axis (sympathetic nervous system) via
ACTH. Proopiomelanocortin (POMC) neurons in the hypothalamus are direct
targets of the lipid regulating (adipostatic) hormone leptin and contribute to
energy homeostasis in regulating appetite and body weight.