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prostacyclin etc... on the other. These two modes of expansion and contraction
constitute the kundalini path as it hyperboles from one extreme to the other...giving
the expansion/contraction gravity warping effect. It is apparent that expansion
phases where there is an influx of spirit, a relaxation and euphoria are associated
with the circulation of vasodilators in the body. The dilation of the blood vessels
lowers blood pressure and this increases fatigue—heart expansion and gravity
expansion periods are always associated with fatigue and the urge to go to ground.
Some of the agents that facilitate this vasodilation would be histamine, serotonin,
acetylcholine, nitric oxide and even endorphins themselves. Studies found that
arteries in an actively contracted state were dilated in a dose dependent manner
by enkephalins and morphine, due perhaps to the presence of opiate receptors
in the vessel walls. Another vasodilator is Adenosine, which plays an important
role in biochemical processes, such as energy transfer—as adenosine triphosphate
(ATP) and adenosine diphosphate (ADP)—as well as in signal transduction as
cyclic adenosine monophosphate, cAMP. If energy production goes up in the
mitochondrias during kundalini, Adenosine might be an important promoter of
the expansion phase. When adenosine enters the circulation, it causes an increase
in coronary vasodilatation.
In order to bring the body back to equilibrium after the expansion phase
the sympathetic nervous system kicks in to bring about vasoconstriction. This
contraction phase is associated with gravity crushing, panic, hypervigilance, desire
for movement, and emotional stress. The agents of this phase include vasopressin,
adrenaline, the catecholamines: epinephrine, norepinephrine and dopamine;
antihistamines and caffeine. This serves to increase heart rate, blood pressure and
raise blood glucose. Endothelin is a vasoconstricting peptide that plays a key part in
vascular homeostasis. It is one of the strongest vasoconstrictors currently studied.
Found in smooth muscle and endothelial cells and is instrumental in increasing
the discharge of sodium through urine and the production of urine by the kidney.
It also stimulates Nitric oxide (NO) release to redilate vessels and mediate vascular
homeostasis. Overproduction of endothelin can cause lung artery hypertension.
Prostacyclin is a prostaglandin produced in the walls of blood vessels that acts as a
vasodilator and inhibits platelet aggregation. It is used in the treatment of primary
pulmonary hypertension.
Prostaglandins are another important factor in the regulation of vascular
homeostasis. Prostaglandins are a large group of fatty acids that regulate cellular
processes, where they are produced. They are not stored but are produced as
needed by cell membranes in virtually every body tissue. They may also act as
messengers for hormones, in that the hormone binds to the cell, increasing the
levels of prostaglandins, which activate a specific cell process. They participate in
a wide range of body functions such as the contraction and relaxation of smooth
muscle, the dilation and constriction of blood vessels, control of blood pressure,
modulation of inflammation, glandular secretion and Ca movement. One such
substance, which stimulates contraction of the uterus, is used clinically to induce
labor. Prostaglandins also control the substances involved in the transmission of