0521779407-21 CUNY1086/Karliner 0 521 77940 7 June 7, 2007 18:59
1498 Urticaria (Dermatology) Urticaria (Rheumatology)➣Hydroxyzine HCl
➣Clemastine fumarate
➣Cyproheptadein HCl
■Second-generation H1 antihistamines
➣Loratidine
➣Cetirizine
➣Fexofenadine
➣Desloratidine
■H2 antihistamines (must be used with H1 blocker)
➣Cimetidine HCl
➣Ranitidine HCl
■Combination H1 and H2 antihistamines
➣Doxepin HCl
■Leukotriene antagonists
➣Montelukast
➣Zafirlukast
■5-Lipoxygenase inhibitors
➣Zileuton
■Corticosteroids
➣Short tapering course for autoimmune urticaria
■Immunosuppressives
➣Cyclosporine, methotrexate, azathioprine, and/or mycopheno-
late mofetil may be useful for chronic urticaria
follow-up
■Laboratory reassessment as dictated by changes in history or phys-
ical exam
complications and prognosis
■Angioedema may be life-threatening
■50% with urticaria alone free of lesions within 1 year; 20% have
involvement >20 years
■75% with combined urticaria and angioedema have episodes >5
yearsURTICARIA AND ANGIOEDEMA (RHEUMATOLOGY)
ALLEN P. KAPLAN, MD
history & physical
■Hives & swelling
■Acute: <6 weeks
■Probably chronic: 6–10 weeks