0521779407-B02 CUNY1086/Karliner 0 521 77940 7 June 4, 2007 20:52
268 Bullous Pemphigoid
Relative: impaired renal function
■Dapsone
➣Side Effects
Idiosyncratic: Hepatitis, mononucleosis-like illness, psycho-
sis, agranulocytosis/leukopenia
Dose-related: Hemolytic anemia, peripheral neuropathy
➣Contraindications
Absolute: History of dapsone allergy, G6PD deficiency
Relative: History of sulfa allergy, severe anemia or hemoglobin
abnormality, ischemic heart disease, peripheral vascular dis-
ease, severe COPD
■Azathioprine
➣Side Effects
Leukopenia, thrombocytopenia, bone marrow suppression,
macrocytic anemia, serious infections, nausea, vomiting, diar-
rhea, increased liver enzymes, fertility impairment
➣Contraindications
Absolute: hypersensitivity to azathioprine, pregnancy, nursing
mother, thiopurine methyltransferase deficiency
Relative: systemic infection
■Mycophenolate mofetil
➣Side Effects
Nausea, vomiting, diarrhea, dysuria, sterile pyuria, bone mar-
row suppression is uncommon, hyperlipidemia
➣Contraindications
Absolute: hypersensitivity to mycophenolate mofetil
Relative: systemic infection, pregnancy
■Cyclophosphamide
➣Side Effects
Bladder malignancy, myeloproliferative or lymphoprolifera-
tive malignancies, sterility, hemorrhagic cystitis, infection,
anaphylaxis, nausea, vomiting, alopecia, leukopenia
➣Contraindications
Absolute: bone marrow depression, hypersensitivity to cyclo-
phosphamide, pregnancy, nursing mother
Relative: leukopenia, thrombocytopenia, decreased liver func-
tion, decreased kidney function
■Methotrexate
➣Side Effects
Transient liver enzyme abnormalities, vomiting, diarrhea,
stomatitis, malaise, fatigue, fever, chills, anemia, leukopenia,