Science - USA (2022-04-08)

(Maropa) #1
SCIENCE science.org

In retrospect, our project was successful
because we operated as a small biotech-
nology company would. We combined the
efforts of scientists and clinicians across
several laboratories, allowing everyone
to contribute their own expertise. We had
weekly meetings as a group to discuss data,
troubleshoot problems, and brainstorm,
where everyone’s opinions and ideas were
equally valued. We were fortunate to op-
erate in an academic climate that encour-
aged us to patent our intellectual property
by working closely with legal experts. As a
graduate student, I had the opportunity to
pitch our approach to biotechnology com-
panies and potential investors, who were
interested in translating our  technology to
large-scale clinical adoption. More recently,
we established a start-up company to ad-
vance the technologies our group has devel-
oped into the clinical stage.
I am amazed how a simple concept has
blossomed into a detailed and optimized
pipeline for developing an innovative ap-
proach to treating cancer. Our environment
fostered teamwork and creativity, allow-
ing us to overcome seemingly impossible
challenges. As I look to the future, I am ex-
cited to see our work advance beyond the
academic realm—one step closer to the end
goal of providing new treatment options
for cancer patients and ultimately hope for
those patients and their families. j

REFERENCES AND NOTES


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  2. A. H. Pearlman et al., Nat. Can. 2 , 487 (2021).

  3. E. Blass, P. A. Ott, Nat. Rev. Clin. Oncol. 18 , 215 (2021).

  4. A. D. Skora et al., Proc. Natl. Acad. Sci. U.S.A. 112 , 9967
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  5. J. Douglass et al., Sci. Immunol. 6 , eabd5515 (2021).

  6. Q. Wang et al., Cancer Immunol. Res. 7 , 1748 (2019).

  7. E. H. Hsiue et al., Science 371 , eabc8697 (2021).

  8. M. S. Miller et al., J. Biol. Chem. 294 , 19322 (2019).

  9. M. S. Hwang et al., Nat. Commun. 12 , 5271 (2021).


10.1126/science.abo4237

8 APRIL 2022 • VOL 376 ISSUE 6589 147-B

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