Small Animal Dermatology, 3rd edition

190 DISEASES/DISORDERS

Pemphigoid Complex

 Very rare.

 Collie, Shetland sheepdog, doberman pinscher and dachshund may be predisposed.

 Mucous membrane pemphigoid: German shepherd dog; median age of onset 6 years.

Epidermolysis Bullosa Acquisita

 Very rare.

 Great Dane; not yet described in cats.

 Male predisposition; earlier age of onset; median 15 months of age.

CLINICAL FEATURES

Pemphigus Complex

 PF:
Transient waves of vesicles and pustules coalescing to crusted patches (Fig-

ure 12.2)

Scales, crust, pustules, epidermal collarettes, erosions, erythema, alopecia, and

footpad hyperkeratosis with fissuring

Ulcerations indicate a deeper disease and/or secondary bacterial infection

Dogs:

Facial lesions: nasal planum, dorsal muzzle, periorbital (“butterfly” pat-

tern), and pinnae (Figures 12.3–12.5)

Footpad margins (Figures 12.6, 12.7)

Truncal patches of crusts, scales, vesicles, and pustules (Figure 12.8)

Mucosal and mucocutaneous lesions rare; due to secondary infection

Cats: facial as well as nipple and ungual fold involvement common

(Figures 12.9–12.11)

Lymphadenopathy, edema, depression, fever, and lameness (if footpads

involved) in more severe or chronic cases; however, patients are often in good

health

Variable pain and pruritus.

 PE:
Similar to PF
Facially confined lesions; rarely footpads
Aggravated by ultraviolet light; seasonality possible in certain geographic loca-

tions

Depigmentation of the nasal planum, dorsal muzzle, lip margins, and eyelid mar-

gins common, and may precede crusting (Figure 12.12)

No oral or mucosal lesions

ANA rarely positive.

 PV:
Oral ulceration frequent and may precede skin lesions
Ulcerative lesions, erosions, epidermal collarettes, blisters, and crusts