Small Animal Dermatology, 3rd edition

198 DISEASES/DISORDERS

Chlorambucil: leukopenia, thrombocytopenia, nephrotoxicity, and hepatotox-

icity

Chrysotherapy: leukopenia, thrombocytopenia, nephrotoxicity, dermatitis,

stomatitis, and allergic reactions

Cyclosporine: vomiting, diarrhea, hirsutism, psoriasiform lichenoid-like der-

matitis

Mycophenolate mofetil: vomiting, diarrhea, lymphopenia

Colchicine: vomiting, diarrhea, rare bone marrow suppression

Immunosuppression: can predispose animal to demodectic mange, cutaneous

and systemic bacterial and fungal infection.

Expected Course and Prognosis – Pemphigus Complex

 PF, PV, PEP/Pveg:
Lifelong therapy with corticosteroids and cytotoxic drugs needed; remission rare
Routine monitoring paramount
Side effects of medications may affect quality of life
May be fatal if untreated (especially PV)
Secondary infections cause morbidity and possible mortality (especially PV).

 PE:
Relatively benign and self-limiting
Oral corticosteroids may eventually be tapered to low maintenance doses or may

be stopped in some patients

Dermatitis worsens if untreated; systemic symptoms are rare

Prognosis fair.

 PP:
Grave prognosis due to underlying neoplasia.

Expected Course and Prognosis – Pemphigoid Complex

 Lifelong therapy necessary.

 In severe cases, aggressive initial intervention is usually required; some cases do not

respond to treatment.

 Chronic cases may be controlled with cycline antibiotics/niacinamide and/or topical

therapy.

 Morbidity is associated with secondary bacterial infection.

Expected Course and Prognosis – Epidermolysis Bullosa Acquisita

 Lifelong therapy may be necessary.

 In severe cases, aggressive initial intervention is usually required; some cases do not

respond to treatment.

 Morbidity is associated with oral lesions and secondary bacterial infection.