CHAPTER 44 SPOROTRICHOSIS 661
Terbinafine:
Dogs 30 mg/kg PO BID to TID: side effects include anorexia, vomiting, diarrhea,
hepatopathy
Cats 30 mg/kg PO q24h: side effects include lethargy, facial pruritus; may becombined with itraconazole.
Cryotherapy: treatment of individual cutaneous lesions in conjunction with oral anti-
fungal therapy.
Amphotericin B:
AMB/desoxycholate or L-AMB/lipid formulations
Dogs: AMB 0.5 mg/kg IV over 4–6h or L-AMB 1–3 mg/kg IV over 2h; three
times/week; fluid diuresis recommended
Cats: AMB 0.25 mg/kg IV over 4–6h or L-AMB 1 mg/kg IV over 2h; threetimes/week; fluid diuresis recommended
AMB may be administered subcutaneously with 300–500 mL sodium chloride0.45%/dextrose 2.5%.
COMMENTS
Patient Monitoring/Prognosis
Reevaluations, including serum chemistries, are recommended every 2–4 weeks to
monitor clinical signs and side effects associated with treatment.
Guarded prognosis: clinical cure reported in 28.6–47.9% of patients.
Zoonotic Potential
CAUTION: this is a zoonotic disease and proper precautions should be taken to pre-
vent infection.
Client education is of paramount importance.
An absence of a break in the skin does not protect against the disease.
Zoonotic transmission from bites and scratches from rodents, parrots, cats, dogs,
horses, and armadillos has been reported.
Clinically healthy cats sharing a household with an infected cat may be a source of
infection.