Small Animal Dermatology, 3rd edition

CHAPTER 46 TUMORS, COMMON SKIN AND HAIR FOLLICLE 673

MAB IBF9: cell surface antigen (protein) present during all phases of the cell

cycle in malignant canine melanoma cell lines; may be helpful in studying

melanoma etiology as well as aiding in immunotherapeutic options.

 Basal cell tumors:
Umbrella term for a heterogenous group of tumors arising from basal cells of the

epidermis, hair follicle epithelium, sebaceous gland, or sweat glands

Basal cell tumors may be benign or malignant

May be triggered by papilloma virus

Majority of these tumors are benign, solitary, and slow growing.

 Sebaceous gland tumors:
Primarily benign (rarely malignant) tumors of the sebocytes
Forms: nodular sebaceous hyperplasia, sebaceous adenoma, sebaceous epithe-

lioma, sebaceous gland adenocarcinoma.

 Hair follicle tumors:
Tumors, typically benign, that arise from germinal hair follicle cells
Classified according to adnexal differentiation
Trichoepitheliomas, pilomatrixoma, trichoblastoma, tricholemmoma, trichofol-

liculoma, dilated pore of Winer.

SIGNALMENT/HISTORY

Breed/Coat Color Predilection

 Squamous cell carcinoma:
Cats: no breed predisposition; black cats may be predisposed to Bowen’s disease;

more aggressive disease in Devon rex

Dogs: giant schnauzer, Scottish terrier, pekingese, boxer, poodle, Norwegian

elkhound, dalmatian, beagle, whippet, and white English bull terrier may be

predisposed; large breeds with black skin and hair coats may be predisposed to

multiple squamous cell carcinoma involving the digits

Solar-induced breed predilections: dogs – dalmatian, whippet, Italian grey-

hound, greyhound, American Staffordshire and bull terrier, beagle, German

short-haired pointer, boxer, basset hound; cats – light or unpigmented skin in

thinly haired regions.

 Melanocytic tumors:
Dogs: dark-skinned individuals predisposed
Airedale terriers, Boston terrier, boxer, chow chow, chihuahua, cocker spaniel,

doberman pinscher, Irish setter, springer spaniel.

 Basal cell tumors:
Cats: Siamese, Himalayan, and Persian
Dogs: cocker spaniel, poodles, sheltie, Kerry blue terrier, Siberian husky.

 Sebaceous gland tumors:
Cats: uncommon; Persians predisposed
Dogs: adenomas/hyperplasia: poodle, cocker spaniel, miniature schnauzer, ter-

rier, shih tzu, Lhasa apso, Siberian husky, wheaten terrier, beagle, dachshund