APPENDIX B DRUG FORMULARY 775
Fludrocortisone acetate(Florinef)
Mineralocorticoid. Used asreplacement therapy inanimals with adrenalatrophy/adrenocorticalinsufficiency. Has highpotency ofmineralocorticoid activitycompared toglucocorticoid activity.
Adverse effects areprimarily related toglucocorticoid effects withhigh doses. Long-termtreatment forhypoadrenocorticism mayresult in glucocorticoidside effects.
Dose should be adjustedby monitoring patientresponse (i.e., monitoringelectrolyteconcentrations). In somepatients, it is administeredwith a glucocorticoid andsodium supplementation.
100
μg (0.1 mg)
tablets.Dog: 0.2–0.8 mg per dogor 0.02 mg/kg q24h po(15–30
μg/kg).Cat: 0.1–0.2 mg per catq24h po.Flumethasone (Flucort)Potent glucocorticoidantiinflammatory drug.Potency is approximately 15×
that of cortisol. Usedto treat inflammatorydisorders when a potentdrug is needed.Corticosteroids producemultiple systemic sideeffects. Adverse effectsare common with chronictherapy.Doses are based onseverity of underlyingdisease.0.5 mg/mL injection. Antiinflammatory uses:0.15–0.3 mg/kg q12–24hIV, IM, SC.Fludrocortisone acetate(Florinef)Mineralocorticoid. Used asreplacement therapy inanimals with adrenalatrophy/adrenocorticalinsufficiency. Has highpotency ofmineralocorticoid activitycompared toglucocorticoid activity.Adverse effects areprimarily related toglucocorticoid effects withhigh doses. Long-termtreatment forhypoadrenocorticism mayresult in glucocorticoidside effects.Dose should be adjustedby monitoring patientresponse (i.e., monitoringelectrolyteconcentrations). In somepatients, it is administeredwith a glucocorticoid andsodium supplementation.100
μg (0.1 mg)
tablets.Dog: 0.2–0.8 mg per dogor 0.02 mg/kg q24h po(15–30μg/kg).Cat: 0.1–0.2 mg per catq24h po.Flumethasone (Flucort)Potent glucocorticoidantiinflammatory drug.Potency is approximately 15×
that of cortisol. Usedto treat inflammatorydisorders when a potentdrug is needed.Corticosteroids producemultiple systemic sideeffects. Adverse effectsare common with chronictherapy.Doses are based onseverity of underlyingdisease.0.5 mg/mL injection. Antiinflammatory uses:0.15–0.3 mg/kg q12–24hIV, IM, SC.(continued)