Small Animal Dermatology, 3rd edition

776 APPENDIX B DRUG FORMULARY

Drug name (trade orother names)

Pharmacology andindications

Adverse effects andprecautions

Dosing information andcomments

Formulations

Dosage (unlessotherwise indicated,dose is the same fordogs and cat)

Flunixin meglumine(Banamine)

NSAID. Acts to inhibitcyclooxygenase (COX)enzyme, whichsynthesizesprostaglandins. Otherantiinflammatory effectsmay occur (such as effectson leukocytes), but havenot been wellcharacterized. Usedprimarily for short-termtreatment of moderatepain and inflammation.

Most severe adverseeffects related to GIsystem. Causes gastritis,GI ulceration with highdoses or prolonged use.Renal ischemia has alsobeen documented.Therapy in dogs should belimited to 4 consecutivedays. Avoid use inpregnant animals nearterm.

Drug interactions

:

Ulcerogenic effects arepotentiated whenadministered withcorticosteroids.

Not approved for smallanimals, but has beenshown in experimentalstudies to be an effectiveprostaglandin synthesisinhibitor.

250 mg packetgranules; 10,50 mg/mL injection.

1.1 mg/kg once IV, IM, SCor 1.1 mg/kg/day 3day/week po.Ophthalmic: 0.5 mg/kgonce IV.

5-Fluorouracil(Fluorouracil)

Anticancer agent.Antimetabolite. Action isvia inhibition with nucleicacid synthesis.

Causes mild leukopenia,thrombocytopenia. CNStoxicity. Do not use in cats.

Used in anticancerprotocols. Consultanticancer treatmentprotocol for precisedosage and regimen.

50 mg/mL vial.

Dog: 150 mg/m

2

once/week IV.Cat: do not use.