APPENDIX B DRUG FORMULARY 777
Fluoxetine (Reconcile[veterinary], Prozac[human])
Antidepressant drug.Used to treat behavioraldisorders, such asobsessive-compulsivedisorders and dominanceaggression. Mechanism ofaction via selectiveinhibition of serotoninreuptake anddownregulation of 5-HT1receptors.
Most common adverseeffects during field trialswere lethargy, reducedappetite, shaking,diarrhea, restlessness,aggression, andvocalization. In cats,nervousness andincreased anxiousnesshave been observed.
Because of long half-life,accumulation in plasmamay take several days toweeks.
Humanformulations: 10and20mgcapsules;4 mg/mL oralsolution. Veterinaryformulations: 8, 16,32, 64 mg chewabletablets.
Dog: 1–2 mg/kg q24h po.Cat: 0.5–4 mg/cat q24hpo.
Fluralaner (Bravecto)Antiparasitic drug.Isoxazoline: selectiveinhibitor of arthropodGABA andL-glutamate-gatedchloride channels.Vomiting, diarrhea.Labeled use: flea and tickpreventative. Off-labelefficacy against sarcoptidmites and demodicosis.Dog chews andtopical: 112.5, 250,500, 1000, and1400 mg/chew ortube. Cat topical:112.5, 250, and500 mg/tube.Dog: 25 mg/kg q12 weekspo.Gabapentin(Neurontin)Anticonvulsant andanalgesic. Gabapentin isan analogue of theinhibitoryneurotransmitter GABA.The mechanism ofanticonvulsant action andanalgesic effects are notknown.Warning: oral solutioncontains xylitol, whichmay be toxic to dogs.Gabapentin has beenused for treatingrefractory epilepsy and asadjunct for analgesia(with other drugs).100, 300, 400 mgcapsules. 100, 300,400, 600, 800 mgscored tablets.50 mg/mL oralsolution.Anticonvulsant dose:2.5–10 mg/kg q8–12h po.For analgesia:10–15 mg/kg q8h po.(continued)