APPENDIX B DRUG FORMULARY 779
Griseofulvin (microsize)(Fulvicin U/F)
Antifungal drug.Incorporates into skinlayers and inhibits mitosisof fungi. Antifungalactivity is limited todermatophytes.
Adverse effects in animalsinclude teratogenicity incats; anemia andleukopenia in cats;anorexia, depression,vomiting, and diarrhea.Do not administer topregnant cats.
A wide range of doses hasbeen reported. Doseslisted here represent thecurrent consensus.Griseofulvin should beadministered with food toenhance absorption.
125, 250, 500 mgtablets; 25 mg/mLoral suspension;125 mg/mL oralsyrup.
50 mg/kg q24h po (up toa maximum dose of110–132 mg/kg/day individed treatments).
Griseofulvin(ultramicrosize)(Fulvicin P/G, Gris-PEG)Same as above.Same as above.Same as above.Ultramicrosize is absorbedto a greater extent, anddoses should be less thanmicrosize.100, 125, 165, 250,330 mg tablets.30 mg/kg/day in dividedtreatments po.Hydrocortisone (Cortefand generic)Glucocorticoidantiinflammatory drug.Hydrocortisone hasweaker antiinflammatoryeffects and greatermineralocorticoid effectscompared withprednisolone ordexamethasone. Alsoused for replacementtherapy.Adverse effects areattributed to excessiveglucocorticoid effects.Dose requirements arerelatedtoseverityofdisease.5, 10, 20 mg tablets. Replacement therapy:1–2 mg/kg q12h po.Antiinflammatory:2.5–5 mg/kg q12h po.Hydrocortisone sodiumsuccinate (Solu-Cortef)Same as hydrocortisone,except that this is arapid-acting, injectableproduct.Same as forhydrocortisone.Same as forhydrocortisone. Preparevials according tomanufacturer’sinstructions.Various size vials forinjection.Shock: 50–150 mg/kg IVq8h for two days.Antiinflammatory:5 mg/kg q12h IV.(continued)