816 APPENDIX B DRUG FORMULARY
Drug name (trade orother names)Pharmacology andindicationsAdverse effects andprecautionsDosing information andcommentsFormulationsDosage (unlessotherwise indicated,dose is the same fordogs and cat)Trimeprazine tartrate(Temaril [Panectyl inCanada])Phenothiazine withantihistamine activity(similar to promethazine).Used for treating allergiesand motion sickness.Adverse effects similar tothose of promethazine.There is evidence thattrimeprazine is moreeffective when combinedwith prednisone fortreatment of pruritus.Combination product isTemaril-P.2.5 mg/5 mL syrup;2.5 mg tablet.0.5 mg/kg q12h po.Trimethoprim +sulfadiazine (Tribrissen,Tucoprim, and others)Combines theantibacterial drug actionof trimethoprim and asulfonamide. Together,the combination issynergistic, with a broadspectrum of activity.Adverse effects primarilycaused by sulfonamidecomponent.Dosage recommendationsvary. There is evidencethat 30 mg/kg/day isefficacious for pyoderma;for other infections,30 mg/kg twice daily hasbeen recommended.30, 120, 240, 480,960 mg tablets (allformulations haveratio of 5:1 sulfa:trimethoprim). Sometrimethoprim-sulfadiazineformulations are nolonger available in US.15 mg/kg q12h po, or30 mg/kg q12–24h po(forToxoplasma:
30 mg/kg q12h po).Trimethoprim +sulfamethoxazole(Bactrim, Septra, andgeneric forms)Combines theantibacterial drug actionof trimethoprim and asulfonamide. Together,the combination issynergistic, with a broadspectrum of activity.Adverse effects primarilycaused by sulfonamidecomponent.Dosage recommendationsvary. There is evidencethat 30 mg/kg/day isefficacious for pyoderma;for other infections,30 mg/kg twice daily hasbeen recommended.480, 960 mg tablet;240 mg/5 mL oralsuspension (allformulations haveratio of 5:1 sulfa:trimethoprim).15 mg/kg q12h po, or30 mg/kg q12–24h po.Tripelennamine citrate(Pelamine, PBZ)Histamine (H) blocker.Similar in action to otherantihistamines. Used totreat allergic disease.Adverse effects similar toother antihistamines.Membersofthisclass(ethanolamines) havegreater antimuscariniceffects than otherantihistamines.There are no clinicalreports of use inveterinary medicine. Noevidence that it is moreefficacious than otherdrugs in this class.25, 50 mg tablets;20 mg/mL injection.1 mg/kg q12h po.