Cell - 8 September 2016
Leading Edge Previews Probing the Diversity of T Cell Dysfunction in Cancer Ryan T. Sowell^1 and Susan M. Kaech1,* (^1) Departme ...
mice in spite of relatively high amounts of PD-1 and Tim-3 on tumor-infiltrating lymphocytes. As metallothionein levels are regu ...
effects of PD-1 blockade in cancer and chronic viral infection (Chen et al., 2015; Zelenay et al., 2015). Furthermore, metal- lo ...
effects of PD-1 blockade in cancer and chronic viral infection (Chen et al., 2015; Zelenay et al., 2015). Furthermore, metal- lo ...
NB-LRR of the Toll interleukin1 receptor (TIR) sub-family show constitutive path- ogen resistance. The resistance requires the f ...
shows weaker SIM binding, supporting a model in which dissociation of CPR5 ho- momeric binding releases CKIs during ETI and driv ...
shows weaker SIM binding, supporting a model in which dissociation of CPR5 ho- momeric binding releases CKIs during ETI and driv ...
aided by the use of site-specific recombi- nation, most commonly using the Cre- Lox system. While very successful in the above s ...
promoter in an adult animal. By having control over the time of injection, the use of viruses can sidestep the issue of devel- o ...
promoter in an adult animal. By having control over the time of injection, the use of viruses can sidestep the issue of devel- o ...
insects to humans and were originally believed to be maladaptive consequences of the host response to infection (Exton, 1997; Ha ...
inflammation that promotes cellular adap- tation to stress caused by the unfolded protein response but is detrimental in the con ...
Leading Edge Review Cellular Metabolism and Induced Pluripotency Jun Wu,1,2,3Alejandro Ocampo,1,3and Juan Carlos Izpisua Belmont ...
using cultured PSCs as a proxy for understanding the metabolic infrastructure of in vivo embryonic cells. In contrast to mouse, ...
2014; Wu et al., 2015). Besides developmental potentials, naive and primed PSCs differ in colony morphology, single cell cloning ...
serum preparations. Improved understanding of the signaling pathways regulating pluripotency led to the development of the groun ...
relevant to naive hPSCs, considering the diverse naive cultures used in different studies. Systemic metabolic profiling to compa ...
in PSCs. Nevertheless, a later study by Vozza et al. used a human hepatocellular carcinoma line to demonstrate that UCP2 regu- l ...
extends beyond just a simple and direct conversion of respira- tory metabolism to glycolysis. Panopoulos et al. demonstrated, co ...
afflicting these patients remain standard of care. Because each cell contains many mitochondrial genomes, mutations affecting mt ...
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